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Njoo, M

Insufficient buffering: Reconstituting GHK-Cu without adequate bacteriostatic saline, or using a solvent that does not adequately buffer the solutions pH, leaves the compound in a form that is more likely to cause tissue irritation on delivery

257 (4 Pt 1): L16373

Adverse Reactions in Patients for Weight Reduction and Long-Term Maintenance Pool of Placebo-Controlled Weight Reduction Trials in Adults with Obesity or Overweight, with or without Type 2 Diabetes (Study 1 and Study 2) ZEPBOUND was evaluated for safety in a pool of two randomized, double-blind, placebo-controlled trials that included 2,519 adult patients with obesity or overweight treated with ZEPBOUND for up to 72 weeks and a 4-week off drug follow-up period (Study 1 and Study 2) [see Clinical Studies (14.1)]