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Abnormal vascular structures formed inside tumors lead to uneven vascular permeability and drug distribution within a tumor mass due to improperly formed and leaky blood vessels with disordered structures
Combined iontophoresis with microneedles increased it 35-fold compared to passive diffusion (J Pharm Sci 2017)
Se ha gravi problemi ai reni (grave insufficienza ai reni o insufficienza ai reni terminale) o se in dialisi
Even normal processes like hormone metabolism contribute to toxicity
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