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Case reports and clinical experience suggest that some cirrhotic patients on stable liver disease have tolerated semaglutide, while others developed complications including worsening portal hypertension, gastrointestinal bleeding, or electrolyte imbalances
Fourniers Gangrene (necrotizing fasciitis of the perineum), a rare but life-threatening infection that requires emergency medical help, is associated with SGLT2 inhibitors like Jaridance
423 These findings further confirmed the central role of the CNS in regulating the anti-inflammatory effects of GLP-1RAs, highlighting the potential application of GLP-1RAs in anti-inflammatory treatment
Pancreatitis has been reported in fewer than 1% of users in clinical trials, while severe dehydration and acute kidney injury occur in less than 0.5% of cases, usually in patients who experience severe vomiting without adequate fluid intake
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