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These two pathways seem to be overactivated in the melanocytes of patients with vitiligo, suggesting that these cells tolerate less the demand for melanin production than those of healthy individuals.63 Even healthy melanocytes undergo cell stress when exposed to certain phenolic compounds such as hydroquinone monobenzyl ether, inducing the production of IL6 and IL8.63,64 Despite the extensive use of antioxidants by patients with vitiligo who seek therapeutic alternatives, the role of this pathogenic mechanism and the application of this knowledge in clinical practice remain controversial

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Table 3 Protein based nanoparticles for immunotherapy in melanoma

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