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Original Articles Basic and Translational Research LRRFIP1 Inhibits White Adipocyte Differentiation by Suppressing the E2F6/C/EBP Axis Lei Zhou, Yuwen Jiao, Jiaming Xue, Xiaoqiang Zhan, Dongmei Wang, Liming Tang Received March 4, 2025 Accepted July 24, 2025 Published online November 12, 2025 DOI: [Epub ahead of print] 1,822 View 62 Download 2 Crossref Abstract PDFSupplementary MaterialPubReader ePub Background To investigate the biological functions of the transcription factor LRR binding FLII interacting protein 1 (LRRFIP1) in white adipocyte differentiation (WAD) and elucidate the underlying molecular regulatory mechanisms involved
IGF-1 exerts its effects through the IGF-1 receptor, which activates a cascade of intracellular signaling pathways that promote cell growth and survival (Kenyon, 2010)
The perspective concludes that GLP-1 therapies should complement not replace exercise, and that improving adherence is now the central challenge in translating exercises proven benefits into real-world impact
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