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Although Nevada regulators investigated and fined the health practitioners involved in administering the peptides, investigators werent able to determine the exact cause of the reaction
Research in skin cultures has suggested that GHK may stimulate the synthesis as well as the breaking down of collagen, glycosaminoglycans, and other components of the skins extracellular matrix like proteoglycans and chondroitin sulfate
Also, the AP1 complex FBJ osteosarcoma oncogene (c-FOS) was upregulated in neuronal cells expressing SOD1 mutations, suggesting dysregulation of these antioxidant response proteins (Kirby et al., 2005)
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