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Discussion Over 2 years, liraglutide with a diet and exercise program was well tolerated, produced sustained weight loss and reduced important cardiovascular risk factors in obese non-diabetic adults

Diarrhoea was among the most frequently reported adverse effects in the Phase 2 NEJM trial, occurring in a dose-dependent pattern and most commonly during dose escalation

Coverage usually requires prior authorization and documentation such as a confirmed diagnosis of type 2 diabetes, recent A1C results, and evidence that first-line treatments like metformin havent been effective

Rapid injection (under 5 seconds for 1 mL) creates a pressurized pocket that can rupture back through the needle tract, losing 8-12% of the dose