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Long-Acting GLP-1 RAs Exenatide (Bydureon) In 1987, scientists discovered that GLP-1 promotes insulin secretion, and five years later, an entero-insulin analogue, Exendin-4, which is 53% homologous to GLP-1, was isolated from the saliva of the Mexican giant lizard, later known as exenatide, which has GLP-1 receptor agonist activity and a half-life of 2.4 hours
In recent months, concerns have emerged linking these medications with mental health side effects, including anxiety and depression
doi: 10.1038/379606a0 20
These are all valid approaches and we will work together to find the right solution, recognising flexibility between these pathways
