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In the evoke and evoke+ trials, 1855 and 1953 people, respectively, were randomised 1:1 to semaglutide or placebo for 156 weeks (104-week main treatment phase and 52-week extension).
Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable
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Unknown Long-Term Effects: The absence of longitudinal human clinical trial data means that long-term safety outcomes from sustained BPC-157 use are not established
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