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Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan [PMID: 15779864] Laboratory literature summary: Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan
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It is one of the most important endogenous (produced in the body) antioxidants that neutralizes free radicals, protects cells from oxidative stress, and maintains normal immune system function
Patients in the HGSH group exhibited significantly higher recurrence rates, and mortality compared to the LGSH group
