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Recent studies by de Oliveira and colleagues have further confirmed these observations, demonstrating that when mice with experimental autoimmune encephalomyelitis (EAE) receive 1,25(OH)2D3 supplementation, it not only enhanced the expression of ZO-1 but also effectively reduces BBB permeability, which is accompanied by noticeable alleviation of disease symptoms
10.1002/ijc.10054 60 NerlandD
plasma half-life after IV/SC bolus is ~1.11.3 h, while implants provide prolonged release and sustained pigmentation without measurable plasma levels by two weeks (early PK/PD studies)
So, when someone goes on weight-loss drugs and substantially reduces their food intake, the likelihood of deficiencies becomes even greater, unless they change their diet to include more nutrient-dense foods. Why protein matters on GLP-1s Gilbert recommends focusing on nutrient density and protein intake above all else
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