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Robert Lash, chief medical officer at the Endocrine Society, highlights the issue by stating that there are only two GLP-1s FDA-approved for weight loss, and patients and doctors should be cautious about taking medication for an off-label reason
Semaglutide: Mimics the GLP-1 hormone to control blood sugar, reduce appetite, and help you feel full longer
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The combination creates a theoretical risk of hypoglycemiadangerously low blood sugarespecially in patients also taking other diabetes medications, though this risk is lower for weight loss patients not on insulin or sulfonylureas
Your health benefits also reverse: Blood sugar: HbA1c rises toward pre-treatment levels within 36 months Blood pressure: Systolic BP increases by 37 mmHg Cholesterol: LDL and triglycerides creep back up Inflammation: C-reactive protein returns to baseline The weight returning is often visceral fat, the dangerous kind around your organs that drives diabetes and heart disease
