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In patients treated with escitalopram for 12 weeks, clinical remission was accompanied by serum reductions in neurotoxic KP metabolites, including 3-HK and QA, and a shift in metabolite ratios favouring a less excitotoxic profile (e.g., reduced QA/3-HK and increased KYNA/QA) [192]

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While the newly identified fragments did not significantly alter Tb TRs enzymatic activityconsistent with the nature of low-affinity ligandsthey provide valuable insights into key interactions of fragments with TR and, together with prior fragment screening campaigns, pave the way towards follow-up chemical optimization into lead compounds

It is commonly used in cosmetic products to improve the visible condition of the scalp and skin without harsh ingredients