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Data availability Source data underlying graphs presented in the main figures can be found in Supplementary Data 1 and are available from the corresponding author on reasonable request

Metabolism of creatine in humans Creatine undergoes limited catabolism in mammalian cells (Wu 2013)

Future human studies will be required to confirm this potential benefit

The genomic analysis provides evidence that the modern gonococcus is not as old as previously thought and shows that strains from the postmodern era (1980-twenty-first century) have evolved from strains belonging to the pre-antibiotic era (pre-1950s) and mainly form a separate clade in the tree