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Persistent or severe cold intolerance accompanied by other symptoms such as extreme fatigue, significant hair loss, constipation, dry skin, depression, or unexplained weight gain despite continued medication use could suggest thyroid dysfunction

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Of note, FSP1 knockdown in cells resulted in blockage of the RAS-selective lethal 3 (RSL3)-induced expression of charged multivesicular protein (CHMP)5 and CHMP6 at the plasma membrane