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The FLOW trial (N=3,533), published in the New England Journal of Medicine in 2024, showed that semaglutide 1.0 mg reduced the composite kidney endpoint by 24% in patients with type 2 diabetes and chronic kidney disease compared to placebo [8], but the trial population was closely monitored
Additionally, monocyte and macrophage marker cluster of differentiation 68 (Cd68) and monocyte chemoattractant protein-1 (Mcp-1) levels were lowered when treated with GIPR/GLP1R agonists
Papoutsi Z, Kassi E, Mitakou S, Aligiannis N, Tsiapara A, Chrousos GP, Moutsatsou P (2006) Acteoside and martynoside exhibit estrogenic/antiestrogenic properties
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