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Most patients start noticing visible brightening within 24 weeks, with full results building over the course of treatment
Retinoids temporarily disrupt the stratum corneum barrier, which is why clinicians recommend against layering other actives early in the process
The effects that sit outside the trial tables Menstrual-cycle changes are widely discussed in patient communities, including irregular or doubled cycles during rapid loss. Trials did not pre-specify them, so the adverse-event tables cannot estimate incidence
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