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Experimental studies in animal models indicate that IL-1 acts upstream of other proinflammatory cytokines, as the administration of an IL-1 receptor antagonist not only attenuates neurodegeneration but also significantly reduces TNF- and IFN- protein levels in the mesencephalon [195]
Dinkova-Kostova, A
Future research priorities should include defining optimal therapeutic sequencing and optimal combination strategies with cardiometabolic agents, including glucagon-like peptide 1 receptor agonists and non-steroidal mineralocorticoid receptor antagonists, refining perioperative interruption management, evaluating primary prevention in high-risk populations and strengthening clinical implementation strategies
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