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Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)

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8,9 Additionally, clinical trials have shown that semaglutide use is associated with reductions in blood pressure, improved lipid levels, and decreased inflammation all factors that play an important role in retinal health