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Patients with pre-existing joint conditions, obesity-related joint loading, or older age may be at greater baseline risk of musculoskeletal symptoms during treatment
Probably due to the set of environmental, microbial and inflammatory factors, which contribute to the progression of the disease (Sukumar and Tadepalli, 2021)
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Fixed-effects models were applied under the assumption of a shared underlying effect size across datasets, while random-effects models accounted for potential heterogeneity among studies
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