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Mainstay treatments are renin-angiotensin-aldosterone system inhibitors, mineralocorticosteroid antagonists and -blockers, and, as mentioned earlier, SGLT-2 inhibitors, especially in people with comorbid diabetes

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An optimal protocol should incorporate stratified randomization based on OS biomarker profiles (e.g., plasma MDA, urinary 8-OHdG) to identify subgroups most likely to benefit

While the two banks and most industry experts are still optimistic that Capital One Financial will be able to clinch the blockbuster, $35 billion acquisition, questions about the combined company's market share in subprime credit card debt have raised flags about competition in the space