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Tirzepatide activates two receptors, GIP and GLP-1, while semaglutide targets GLP-1 alone, which explains its stronger appetite and glucose effects in trials

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[15] [16] Symptoms requiring medical review include: Persistent or severe headaches, particularly if different from usual headache patterns Significant mood changes, depression, or suicidal thoughts Confusion, disorientation, or marked changes in cognitive function Any symptoms causing concern to the patient The most commonly reported neurological adverse effect is headache, which occurs in approximately 14% of patients during clinical trials