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The FDA has issued cautions about reports of adverse events associated with compounded semaglutide, such as severe gastrointestinal difficulties and unanticipated side effects

These benefits were further supported by the results of the SUMMIT trial, which investigated tirzepatide, a dual GLP-1/glucose-dependent insulinotropic polypeptide receptor agonist, in patients with HFpEF with or without T2D

Also, the NGT relies on expert consensus rather than objective clinical research data, is subject to personal interpretation, may be influenced by factors such as hospital or healthcare system policies, and does not account for long-term outcomes, cost analyses, or adverse effects