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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (47) and small early-phase clinical trials (8, 9)
GE2 reduced cytokine levels in the amygdala of WD-fed males (F( 1,12 ) = 2.045, R 2 = 0.146, p = 0.018), but not WD-fed females ( p = 0.157)
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This work was supported by the National Natural Science Foundation of China (81790640, 32070989, 31872766, 31571075, 82070993, and 31571072), the Ministry of Science and Technology of China (2011CB504602 and 2015AA020512), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), ZJLab, Shanghai Center for Brain Science and Brain-Inspired Technology, and Sanming Project of Medicine in Shenzhen (SZSM202011015)
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