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Caution is also advised in people with severe gastrointestinal motility disorders or a history of pancreatitis

The cost, concerns around low calorie goals, and potential pitfalls of food tracking are among other downsides of the program

Seek advice before taking ibuprofen if you: Have been diagnosed with chronic kidney disease or have reduced kidney function Have a history of stomach ulcers, gastrointestinal bleeding, or inflammatory bowel disease Have heart failure, coronary artery disease, or have previously had a heart attack or stroke Are taking multiple medications, including aspirin, anticoagulants (such as warfarin or DOACs), corticosteroids, or other NSAIDs Are taking an ACE inhibitor or ARB plus a diuretic (the 'triple whammy' combination with NSAIDs increases kidney injury risk) Are pregnant or breastfeeding Are aged over 65, as the risk of adverse effects increases with age Need pain relief for more than a few days or require regular analgesia Contact your GP or seek urgent medical attention if you experience: Severe, persistent abdominal pain , particularly if radiating to the back, which could indicate pancreatitisa rare but serious side effect of Trulicity Black or tarry stools, or vomiting blood, suggesting gastrointestinal bleeding Sudden swelling of the ankles, face, or hands, or reduced urine output, which may indicate kidney problems Chest pain, shortness of breath, or signs of an allergic reaction such as rash, swelling, or difficulty breathing Persistent nausea, vomiting, or diarrhoea that prevents adequate fluid intake, increasing dehydration risk Regular medication reviews with your GP or diabetes specialist nurse are important, particularly when your treatment regimen changes

95% CI, 1.26-1.56), but shorter duration (=26 weeks) of treatment was not (RR 0.79)