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In a recent 12-week, randomized, placebo-controlled trial in untreated hypertensive subjects, daily intake of aged garlic extract (1.2 g of which contained 1.2 mg of S-allyl-L-cysteine [SAC]) was shown to significantly lower SBP by 11 mm Hg and DBP by 6 mm Hg on average in 50%-60% of participants, but reductions in blood pressure were not reported in 40%-50% of participants compared to placebo (110)
Penetration enhancers, appropriate pH, and stable copper chelation all affect whether the peptide reaches the dermis
3A, B, S4A, B, and Supplementary Data S3)
Separate iron and antioxidant doses by at least four to six hours
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