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Medical Weight Loss Program While weight loss with medications like semaglutide is helping many people transform their lives and health, this kind of rapid weight loss can have its own side effects

10.1016/j.ijid.2021.03.032 150 PareekM.GreenawayC.NooriT.MunozJ.ZennerD

Instead of pushing every patient to the maximum dose, clinicians may maintain individuals at lower doses that still produce meaningful metabolic effects

| Substance | Receptor profile | Trial | Weight change | Placebo | | --- | --- | --- | --- | --- | | Retatrutide | GIP/GLP-1/glucagon | Phase 2 (48 wk) | -8.7 to -24.2 % | -2.1 % | | Tirzepatide | GIP/GLP-1 | SURMOUNT-1 (72 wk) | -16.0 to -22.5 % | -3.1 % | | Semaglutide | GLP-1 | STEP 1 (68 wk) | -14.9 % | -2.4 % | | Cagrilintide + semaglutide | Amylin + GLP-1 | Phase 1b (20 wk) | -15.7 to -17.1 % | -9.8 %* | | CagriSema | Amylin + GLP-1 | REDEFINE 1 (68 wk) | -20.4 % | -3.0 % | *Comparator arm semaglutide alone