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A missense mutation in the B-crystallin chaperone gene causes a desmin-related myopathy
592,593 Moreover, due to the decrease of 3-hydroxykynurenine (a cytotoxic metabolite of KMO), the mice that lack active kynurenine 3-monooxygenase (KMO) will not develop into AKI after I/R injury
High IGF-1 Possible increased cancer risk, accelerated cell proliferation without adequate repair balance
In terms of epidemiology, the reported prevalence of altitude illnesses varies significantly due to differences in sample size, ethnic population, diagnostic methods/criteria, study design and environmental conditions
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