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As happens with oxygen use, wich allows a very active life style but has as its "side effect" the production of noxious ROS, a very active immune system is designed to provide protection against the risk of contracting infections and tumours to which we are chronically exposed, but it has a "price", i.e., that if the oxygen-inflammationsupported functions and resulting stress are not well controlled or the aging organism lacks a satisfactory individual adaptation to this stress, the senescent process accelerates(35)
These are fundamentally different processes even though both involve new blood vessel formation
Detection of the HIF1 transcriptional activity The HIF1 transcriptional activities were detected by a dedicated HIF1 transcriptional activity assay kit (Cayman, 10006910), following the manufacturers instructions
