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Every year, thousands of people (children and adults) are injured, and hundreds die from taking too much of the easy-to-obtain OTC medication used to reduce pain named acetaminophen (initially marketed in 1959 under the brand name Tylenol)
Additionally, aromatase (CYP19A1) is expressed by breast adipose stromal cells and cancer-associated fibroblasts, which plays a crucial role in oestrogen production both locally and systemically, particularly in women who undergo through menopause (186)
The development of resistance is rare during the recommended treatment period, but may be developed during an extended treatment period
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