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The drugs dampen activity in brain regions involved in appetite, reward and motivation, says Dr

Regions such as the hippocampus and posterior cingulate cortex exhibit early declines in mitochondrial efficiency and energy availability, contributing to synaptic failure long before widespread neuronal loss occurs

Gimbrone and Garca-Cardea 2016)

Graphical Abstract Similar content being viewed by others Introduction The tight junction-connected, non-fenestrated brain capillary endothelial cells in cross-talk with the neighboring pericytes and astroglial endfeet create the dynamic anatomical and functional unit called as bloodbrain barrier (BBB) [1]