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The obstacle was that native GLP-1 is cleaved by dipeptidyl peptidase-4 between its second and third residues almost immediately, leaving a circulating half-life measured in a couple of minutes
doi:10.1016/j.ejps.2017.03.020 48
GLP-1 medications, such as semaglutide and tirzepatide, are often recommended for long-term management of PCOS
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