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Elevated cAMP activates PKA, which phosphorylates/activates CREB, driving expression of MITF and MITFdependent melanogenic genes, including tyrosinase (TYR), TYRP1, and DCT/TYRP2

The standard dose of TA is 500 mg/day as single or two divided doses and the duration of therapy ranging from 2 to 6 months

Numerous national health organizations have issued safety warnings regarding both melanotan 1 and 2, since their mechanism of action centers on the stimulation of melanocytes, the type of skin cell that can develop into cutaneous malignant melanoma (CMM)

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