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The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )

This prompted Moore's group to study the effects of duodenal extracts given daily by mouth to three patients recently diagnosed with juvenile diabetes (type 1)

Results from two studies found no association between the use of GLP-1 receptor agonists and increased risk for suicide, suicidal thoughts or depression, findings published in JAMA Internal Medicine showed

Urinary soluble CD163 is useful as liquid biopsy marker in lupus nephritis at both diagnosis and follow-up to predict impending flares