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Acknowledgments Under the direction of the authors, medical writing and editorial support, including the literature search, were provided by Graham Allcock of Axis, a division of Spirit Medical Communications Group Limited (funded by Novo Nordisk A/S)

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Many women ultimately find that a combination approach, using compounds from different mechanism categories, produces the best results

The HFD feeding was suggested to induce HDAC3 activity, which was associated with increased body weight gain and blood glucose concentrations ( Figure 2 ), while supplementation with butyrate, a SCFA, was able to reduce weight gain in HFD fed mice, presumably via HDAC3 dependent mechanisms