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Gclc is required for T cell-independent and -dependent B cell immune responses Next, we aimed to understand how the metabolic perturbations caused by B cell-specific Gclc ablation impinge on immune responses and in particular how the impaired mitochondrial metabolism affects the antibody response
After initial correction, some individuals may require ongoing maintenance injections (often monthly) if they cannot adequately absorb B12 from diet or oral supplements
Hausner H, Karsbl JD, Holst AG, Jacobsen JB, Wagner F, Golor G, et al
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