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Strikingly, however, the proteomic analysis also revealed a drastic induction in heme oxygenase 1 (HMOX1) levels, which has an important function in protecting cells from oxidative damage 53 , in cells treated with the CRBN-based PROTAC 1a or VHL-based PROTAC 2c as well as in cells treated with CCW16 only ( Figure 2D, Supplementary Table I)
Combined approaches often show initial improvements within 2-3 weeks
In most cases, this translates into a 10% decrease in insulin requirements to maintain the same blood sugar levels
The functional SAT1 enzyme is a 171 amino acid protein
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