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Conflating the two is the central error in most online content on this topic, and it is the error this article exists to prevent
In pediatric populations, congenital hypothyroidism and untreated iodine deficiency remain major causes of intellectual disability worldwide (81)
Patients often report increased energy within the first week due to L-carnitines mitochondrial effects, but weight loss velocity accelerates most significantly between weeks 4 and 8 as hepatic steatosis resolves and VLDL export normalizes
This doesnt mean the treatment has failed only that maintenance therapy is often required for long-term results
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