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408 Spatial metabolomics, built on mass spectrometry imaging, enables high-resolution mapping of metabolites across histological structures, providing insights into spatially regulated metabolic reprogramming that underlies therapeutic resistance
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Endpoints for metformin were derived from concentrationtime curves from the last dosing until 30 h after the last of seven repeated doses of metformin alone, with SNAC or with oral semaglutide at steady state (days 4, 20, and 78, respectively)
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