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The post names patients with severe gastrointestinal intolerance, a medullary thyroid cancer history, pancreatitis risk, or dehydration concerns as potentially requiring a cap below the top tier

This stress may be linked to amyloid formation, associated with neurodegenerative diseases

In the retatrutide Phase 2 trial, discontinuation due to adverse events ranged from 6% at 4 mg doses to 16% at 12 mg, compared with 0% for placebo [1]