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In the exploration of the known pathways of cell resistance to ferroptosis, the contents of 15-LOX, ACSL4, and LPCAT3 did not differ significantly, indicating that the ferroptosis resistance of M1 macrophages does not rely on traditional pathways
Despite promising preliminary findings, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses
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Cleo Ryals of the University of North Carolina at Chapel Hill also presented at the 2025 SABCS indicated there may be a connection between the use of GLP-1 agonists and reduced circulating tumor activity, suggesting that these medications may have benefits for patients with breast cancer beyond weight loss
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