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Reviews on the topic highlight that while clinical trials are essential to ensure a drug's safety and performance prior to widespread (routine) administration, their inherent rigidity in participant selection leaves critical gaps regarding how these medications perform in routine clinical practice, especially among elderly or frail patients and similar high-risk populations

Tirzepatide lowers appetite fast, and this can throw off regular eating patterns

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Some experts suggest it may help support a healthier microbiome in people with gastrointestinal ailments and inflammatory bowel diseases