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Adults with a BMI of 30 kg/m or higher-or at least 27 kg/m with weight-related comorbidities-who have not succeeded with lifestyle changes alone and who do not have contraindications such as heart disease, uncontrolled hypertension, glaucoma, hyperthyroidism, pregnancy, or a history of drug abuse
Whilst these are not caused by GLP-1 medications, they require urgent assessment regardless of current treatment
Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one
Some patients may experience changes in liver enzyme levels, which is why regular monitoring is recommended during treatment
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