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While most population-relevant exclusions are not population-specific in their wording, the higher prevalence of hepatic steatosis reported in some Asian subgroups, combined with the very high prevalence of severe-hepatic-impairment exclusion criteria (50.3% of trials), may exert differential impact in practice (S5 Table)
Given the global increase in the use of GLP-1 RAs and the growing number of patients at risk, further investigation into their neurological safety profile is warranted
Suggested Use: Take one capsule daily 30 minutes prior to a meal
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