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Amylin receptor signaling primarily engages Gs proteins, which stimulate adenylate cyclase and increase intracellular cyclic AMP concentrations
Synthesized as pre-proglucagon, differential cleavages produce glicentin, oxyntomodulin, GLP-1 and GLP-2
In a post hoc analysis of the assessment of weekly administration of LY2189265 [dulaglutide] in diabetes trials, dulaglutide (1.5 mg once weekly) improved liver enzymes over 6 months, indicating potential liver fat reduction
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