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Protein digestion begins in the stomach when your stomach acid (hydrochloric acid or HCl) starts to break down the protein and also activates digestive enzymes known as proteases
Three metabolic pathways are known: - Glucuronidation (about 40% of the metabolism of the drug) - Sulfate conjugation (20-40%) - N-hydroxylation and rearrangement, then GSH conjugation (15%): the hepatic cytochrome P450 enzyme metabolizes the drug, forming a metabolite known as NAPQI (N-acetyl-p-benzo-quinone imine) that is irreversibly conjugated with sulphydryl group of glutathione
Chaiwat Songsiriphan COOLSCULPTING KOL [KEY OPINION LEADER] M.D., Chiang Mai University Cert
35 (2), e202000203 (2020)
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