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In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factormediated pathways

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These include ribosome-associated quality control during protein synthesis, molecular chaperone systems such as heat shock proteins that ensure proper folding and conformational stability and intracellular trafficking pathways that guide nascent proteins to their correct destinations