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Oral administration in systemic research For systemic endpoints (tendon, ligament, muscle, cardiac), oral administration is pragmatically useful when: Repeated parenteral injections are impractical for the model A translational research question addresses oral route viability Drinking-water dosing allows long-duration protocol administration For foundational preclinical work aimed at mechanism characterisation or replication of flagship studies, parenteral routes remain the standard

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Mycotoxins upregulate the expression of senescence markers -H2AX, senescence-associated -galactosidase, p53, p16, and senescence-associated secretory phenotype (SASP) inflammatory factors