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110,111 Through a series of complex disruptions of the genome, cells acquire the accumulation of deleterious alterations irreversibly to survive in purifying selection (removing deleterious genetic variations) of human germline evolution, further obtaining fitness, attenuating tumor cell attrition and evolving to malignancies
10.3389/fnins.2017.00755 63 KandhareA
SGLT2 inhibitors (SGLT2i) SGLT2i were developed to manage type 2 diabetes by reducing glucose reabsorption through the selective inhibition of SGLT2 expression in proximal tubules [154]
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