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They feel like the medication isnt working because the scale hasnt moved much
Within the mitochondria, electron leakage from complexes I and III of the electron transport chain generates superoxide, which is subsequently converted to hydrogen peroxide by superoxide dismutase (SOD2)
Dehydration puts additional strain on the kidneys
Interestingly, some of these benefits appear to occur independently of glucose control, suggesting that SGLT2 inhibitors may directly influence cellular mechanisms such as AMPK activation and improved mitochondrial function
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